Brain & Spine Tumor Center at USC University Hospital

Brain & Spine Tumor Center at USC University Hospital

Brain & Spine Tumor Center at USC

The Brain Tumor Center @ USC’s internationally reorganized team of clinical and translational experts are pushing the limits of clinical care. Aiming to make bio-marker analysis part of the standard practice of care and deliver personalized treatment options. This forward thinking approach highlights our ability to better predict successful treatment before a therapy is given to a patient.

"It is important for patients to understand that no two tumors are alike. Our focus at the USC Brain & Spine Tumor Center is to give treatment options tailored to the specific needs of each patient and their tumor."

- Thomas Chen, MD, PHD - USC Neurological Surgery

Learn more about our program Make an Appointment

"At the USC Brain & Spine Tumor Center, every Patient is part of the cure."

- Naveed Wagle M.D., Director, Clinical Neuro-Oncology

USC University Hospital placed among the best hospitals in the U.S. News & World Report 21st annual rankings of “America’s Best Hospitals.”

The Brain & Spine Tumor Center, part of USC Norris Comprehensive Cancer Center.

Get the latest information about current and upcoming trials.

• Ongoing Clinical Trials
• Upcoming Clinical Trials

Recent USC Peer Reviewed Articles

Research findings by USC Brain & Spine Tumor Center and in cooperation with their research partners.

		Noscapine inhibits tumor growth in TMZ-resistant gliomas. Cancer Letters 12/22/2011 Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC
		A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer 11/1/2011 Couldwell WT, Surnock AA, Tobia AJ, Cabana BE, Stillerman CB, Forsyth PA, Appley AJ, Spence AM, Hinton DR, Chen TC.
		Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms. Neurosurg Focus 5/1/2011 Pham MH, Zada G, Mosich GM, Chen TC, Giannotta SL, Wang K, Mack WJ.
		Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer 3/28/2011 Chen TC, Wang W, Golden EB, Thomas S, Sivakumar W, Hofman FM, Louie SG, Schönthal AH.

USC Brain & Spine Tumor Center: Latest Clinical Trials

Now Enrolling : Clinical Trials
Newly diagnosed glioblastoma multiforme (GBM)
	Novocure TTF-100A device combined with temozolomide A non-invasive, non-pharmacological treatment for patients who have completed chemo-radiation. (http://clinicaltrials.gov/ct2/show/NCT00916409)
	Rindopepimut combined with temozolomide for newly diagnosed GBM patients who express EGFR VIII in their tumor tissues A tumor vaccine combined with monthly temozolomide for patients’ who have EGFR vIII + tumors. (http://clinicaltrials.gov/ct2/show/NCT01480479)
Upcoming : Clinical Trials
Metastatic Cancer
	GRN1005 Alone or in Combination with Trastuzumab in Breast Cancer patients with Brain Metastatses An experimental drug that may have better ability to enter the CNS and treat breast cancer. (http://clinicaltrials.gov/ct2/show/NCT01480583)
Newly diagnosed glioblastoma multiforme (GBM)
	Trans Sodium Crocetinate combined with cranial radiation for newly diagnosed GBM An experimental drug that may work synergistically with radiation by improving tumor oxygenation (http://clinicaltrials.gov/ct2/show/NCT01465347)
Recurrent diagnosed glioblastoma multiforme (GBM)
	Rindopipimut versus avastin for recurrent or progressive GBM patients who express EGFR VIII in their tumor tissues comparing a tumor vaccine with bevacizumab for patients with recurrent tumor tested + for EGFRvIII. (http://clinicaltrials.gov/ct2/show/NCT01498328)
	Stem cell tumor lysate for recurrent GBM A tumor vaccine against glioblastoma stem cells at the time of disease progression. (#)